Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Good
Based on 120 Reviews
8
Supplement Facts
Serving Size: 1 Veggie Capsule
Serving Per Container: 60
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
200 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
9
We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
Read More
This study focused on the potential protective effects of Coenzyme Q10 (CoQ10) against heart damage caused by copper toxicity. We induced myocardial injury in rats using daily doses of copper sulfate for a week, observing detrimental effects on heart function.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
Read More
9
We explored the effectiveness of coenzyme Q10 in treating heart failure by analyzing data from 33 randomized controlled trials. These studies collectively aimed to determine whether coenzyme Q10 could improve outcomes for people suffering from heart disease.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Read More
Most Useful Reviews
9
Boosts heart function
210 people found this helpful
This "enzyme of youth" fuels our body and boosts energy. I buy it for my family, and it significantly helps my 69-year-old mother. Coenzyme Q10 is crucial for heart support and energy production, especially important as levels decrease with stress and statins. Take as advised by a healthcare professional.
Read More
9
Reduces fatigue
81 people found this helpful
My friends and I have been taking coenzyme Q10 for years. The effects are particularly pronounced for older individuals with heart issues, but even younger people experience increased energy. As an athlete, I rely on it daily. I recommend a starting dosage of 100 mg with fat for better absorption.
Read More
9
Lowers heart attack risk
48 people found this helpful
The pure coenzyme significantly enhances heart muscle function, reducing the risk of heart attacks substantially.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
- All Researches
9
We aimed to investigate the effects of Coenzyme Q10 (CoQ10) on heart health in the context of CDKL5 deficiency disorder (CDD). CDD is a complex condition caused by mutations in the CDKL5 gene, leading to severe developmental challenges and systemic issues, including oxidative stress.
Our study demonstrated that CoQ10 supplementation can significantly reduce harmful levels of reactive oxygen species (ROS) and help restore a balanced state of glutathione in the body. This is important because oxidative stress is believed to contribute to various health problems, including those affecting the heart.
Additionally, we found that CoQ10 not only improved markers of cellular health and proliferation in a human neuron model but also provided protective effects against lipid peroxidation and DNA damage in the hearts of a mouse model of CDD.
Overall, our findings suggest that CoQ10 may play a crucial role in alleviating oxidative stress and protecting heart health in individuals with CDD, offering a potential therapeutic avenue worth exploring further.
Our study demonstrated that CoQ10 supplementation can significantly reduce harmful levels of reactive oxygen species (ROS) and help restore a balanced state of glutathione in the body. This is important because oxidative stress is believed to contribute to various health problems, including those affecting the heart.
Additionally, we found that CoQ10 not only improved markers of cellular health and proliferation in a human neuron model but also provided protective effects against lipid peroxidation and DNA damage in the hearts of a mouse model of CDD.
Overall, our findings suggest that CoQ10 may play a crucial role in alleviating oxidative stress and protecting heart health in individuals with CDD, offering a potential therapeutic avenue worth exploring further.
Read More
This study focused on the potential protective effects of Coenzyme Q10 (CoQ10) against heart damage caused by copper toxicity. We induced myocardial injury in rats using daily doses of copper sulfate for a week, observing detrimental effects on heart function.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
Read More
9
We explored the effectiveness of coenzyme Q10 in treating heart failure by analyzing data from 33 randomized controlled trials. These studies collectively aimed to determine whether coenzyme Q10 could improve outcomes for people suffering from heart disease.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Read More
9
We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
Read More
9
CoQ10 mitigates chemotherapy-related heart damage
We aimed to explore the effects of Coenzyme Q10 (CoQ10) on heart health in the context of Doxorubicin treatment, a common chemotherapy known for its side effects, including heart damage. Our study involved 27 white albino rats, which we divided into three groups: one receiving CoQ10, another receiving Doxorubicin, and a final group receiving both treatments.
After the treatment period, the rats were humanely sacrificed to analyze the condition of their heart and lung tissues. We prepared slides of these tissues for microscopic examination. The results revealed that Doxorubicin exposure led to significant abnormalities in the cellular structures of the heart and lungs, indicating damage caused by the drug.
However, the introduction of CoQ10 appeared to mitigate these negative effects. The CoQ10 treatment helped restore the structure of the tissues, suggesting that it plays a protective role against the damaging impact of Doxorubicin.
Overall, our findings indicate that CoQ10 may be beneficial in maintaining heart health during chemotherapy by counteracting some of the harmful effects posed by Doxorubicin.
After the treatment period, the rats were humanely sacrificed to analyze the condition of their heart and lung tissues. We prepared slides of these tissues for microscopic examination. The results revealed that Doxorubicin exposure led to significant abnormalities in the cellular structures of the heart and lungs, indicating damage caused by the drug.
However, the introduction of CoQ10 appeared to mitigate these negative effects. The CoQ10 treatment helped restore the structure of the tissues, suggesting that it plays a protective role against the damaging impact of Doxorubicin.
Overall, our findings indicate that CoQ10 may be beneficial in maintaining heart health during chemotherapy by counteracting some of the harmful effects posed by Doxorubicin.
Read More
User Reviews
USERS' SCORE
Good
Based on 120 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Boosts heart function
210 people found this helpful
This "enzyme of youth" fuels our body and boosts energy. I buy it for my family, and it significantly helps my 69-year-old mother. Coenzyme Q10 is crucial for heart support and energy production, especially important as levels decrease with stress and statins. Take as advised by a healthcare professional.
Read More
9
Reduces fatigue
81 people found this helpful
My friends and I have been taking coenzyme Q10 for years. The effects are particularly pronounced for older individuals with heart issues, but even younger people experience increased energy. As an athlete, I rely on it daily. I recommend a starting dosage of 100 mg with fat for better absorption.
Read More
9
Lowers heart attack risk
48 people found this helpful
The pure coenzyme significantly enhances heart muscle function, reducing the risk of heart attacks substantially.
Read More
9
Prevents heart disease
43 people found this helpful
CoQ10 is essential for energy production and critical for maintaining heart health. Its levels decline with age and poor diet. Starting supplementation is crucial for those with heart disease, as it facilitates blood flow and acts as an antioxidant.
Read More
9
Good for heart function
29 people found this helpful
Coenzyme Q10, generated in the body, is crucial for energy production and protects cells from free radicals. I take 200mg daily to support my heart and improve recovery after exercise. Post 40, it's advisable to maintain this dosage. Stay healthy!
Read More
Frequently Asked Questions
9
Increases energy levels
7 people found this helpful
This is the best product from Doctor's Best, featuring high absorption. I take it post-heart attack for energy recovery. A dosage of 200mg helps prevent fatigue during the day, and the added BioPerine improves digestibility. After two weeks, I feel energised all day.
9
Angina relief
3 people found this helpful
Q10 is excellent! I no longer experience heart failure and have been able to reduce my cardiac medications. It calms my angina effectively.
9
Heart health improvement
6 people found this helpful
Useful for those over 40. I’ve taken this coenzyme daily for two years, aiding my heart disease and improving my cardiogram. I also combine it with omega and vitamins while being physically active. I recommend it particularly for those over 40.
9
Provides energy boost
9 people found this helpful
Coenzyme Q10 is a remarkable supplement for combating fatigue and slow energy production. It’s vital for heart function and I'm impressed with the energy boost I've experienced. I recommend it, particularly for those over 50. Good quality product!
9
Improves cardiovascular system
20 people found this helpful
I take Coenzyme Q10 several times a year to boost energy and support my heart, especially past 40. This manufacturer offers quality ingredients and good dosages. Since starting, I've noticed improved heart strength and mental clarity. Please like if this review helped!
10
Effective coenzyme
1 people found this helpful
This "high absorption rate coenzyme" is fantastic! Since I began taking it, my abnormal heartbeats have disappeared, and I sleep better. The effects are quite noticeable.
9
Tachycardia alleviated
1 people found this helpful
I've been taking CoQ10 for two months alongside Biotin and multivitamins. My tachycardia, which I’ve had since I was 17, has vanished, and my husband also uses it for heart support.
9
Boosts heart function
210 people found this helpful
This "enzyme of youth" fuels our body and boosts energy. I buy it for my family, and it significantly helps my 69-year-old mother. Coenzyme Q10 is crucial for heart support and energy production, especially important as levels decrease with stress and statins. Take as advised by a healthcare professional.
9
Reduces fatigue
81 people found this helpful
My friends and I have been taking coenzyme Q10 for years. The effects are particularly pronounced for older individuals with heart issues, but even younger people experience increased energy. As an athlete, I rely on it daily. I recommend a starting dosage of 100 mg with fat for better absorption.
9
Functional heart support
5 people found this helpful
I began with a 300mg dosage of CoQ10 due to heart issues, noticing problems with palpitations and rhythm changes. Following this, I switched to a maintenance dose of 200mg. Everything has improved, and I feel great. I recommend this product.
We explored how Coenzyme Q10 (CoQ10) combined with ultrasound-targeted microbubble destruction (UTMD) could help treat diabetic cardiomyopathy (DCM) in rats. In our study, we took a close look at the heart health of diabetic rats after using these innovative treatments. Specifically, we used a group of 60 male rats, inducing diabetes in most of them and setting up control groups for comparison.
After treating the rats for 12 weeks, we observed that the group receiving CoQ10 encapsulated in nanoliposomes combined with UTMD showed promising signs of improvement. Notably, their heart structure appeared intact, and they had improved heart function metrics like left ventricular dimensions. We found significant reductions in harmful indicators of heart stress and damage among the treatment group compared to those not receiving the combined therapy.
It's important to mention that while CoQ10 seemed beneficial in this context, the study did not isolate the effects of CoQ10 alone. This means we cannot definitively conclude its exclusive role without considering the combined effect with UTMD. Overall, our findings indicate that CoQ10, especially with the support of advanced delivery techniques, can contribute to better heart health in diabetes-affected conditions.
After treating the rats for 12 weeks, we observed that the group receiving CoQ10 encapsulated in nanoliposomes combined with UTMD showed promising signs of improvement. Notably, their heart structure appeared intact, and they had improved heart function metrics like left ventricular dimensions. We found significant reductions in harmful indicators of heart stress and damage among the treatment group compared to those not receiving the combined therapy.
It's important to mention that while CoQ10 seemed beneficial in this context, the study did not isolate the effects of CoQ10 alone. This means we cannot definitively conclude its exclusive role without considering the combined effect with UTMD. Overall, our findings indicate that CoQ10, especially with the support of advanced delivery techniques, can contribute to better heart health in diabetes-affected conditions.
9
We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
9
We examined the protective effects of coenzyme Q10 (CoQ10) against heart damage caused by cadmium (Cd) exposure in mice. This study was designed to investigate how CoQ10 affects heart health by addressing oxidative stress and inflammation, both of which are known to contribute to heart disease.
Mice were given a dose of cadmium, and after a week, received daily supplements of CoQ10 for two weeks. We found that cadmium exposure significantly harmed the hearts of the mice, as indicated by increased levels of heart injury markers and visible damage in heart tissues.
Remarkably, CoQ10 treatment not only reduced these injury markers but also improved the harmful tissue changes produced by cadmium. CoQ10 was found to lower oxidative stress levels and inflammation by impacting specific inflammatory pathways in the heart.
This suggests that CoQ10 has the potential to play a vital role in protecting the heart from damage, particularly from environmental toxins like cadmium. Overall, our findings highlight CoQ10's promising benefits for heart health, shedding light on its ability to counteract the effects of cardiotoxic substances.
Mice were given a dose of cadmium, and after a week, received daily supplements of CoQ10 for two weeks. We found that cadmium exposure significantly harmed the hearts of the mice, as indicated by increased levels of heart injury markers and visible damage in heart tissues.
Remarkably, CoQ10 treatment not only reduced these injury markers but also improved the harmful tissue changes produced by cadmium. CoQ10 was found to lower oxidative stress levels and inflammation by impacting specific inflammatory pathways in the heart.
This suggests that CoQ10 has the potential to play a vital role in protecting the heart from damage, particularly from environmental toxins like cadmium. Overall, our findings highlight CoQ10's promising benefits for heart health, shedding light on its ability to counteract the effects of cardiotoxic substances.
7
We explored the application of coenzyme Q10 alongside lisinopril in treating a 74-year-old woman suffering from heart complications due to a late-onset myocardial infarction. The patient arrived at the emergency room with signs of a ventricular septal rupture (VSR), a serious condition often arising from heart attacks, leading to critical blood pressure drops.
Upon introducing lisinopril and coenzyme Q10, we observed a promising improvement in her hemodynamic stability over a three-month period. This might suggest that coenzyme Q10, in conjunction with lisinopril, could enhance energy production at the cellular level and support tissue healing. Though VSR is typically managed surgically, this case highlights a potential non-surgical approach that could contribute to patient survival in resource-limited settings.
It is important to note, however, that coenzyme Q10 was combined with another treatment, thus making it challenging to determine its isolated impact. Despite this, the case provides valuable insights into how nutritional supplements could potentially play a role in heart disease management.
Upon introducing lisinopril and coenzyme Q10, we observed a promising improvement in her hemodynamic stability over a three-month period. This might suggest that coenzyme Q10, in conjunction with lisinopril, could enhance energy production at the cellular level and support tissue healing. Though VSR is typically managed surgically, this case highlights a potential non-surgical approach that could contribute to patient survival in resource-limited settings.
It is important to note, however, that coenzyme Q10 was combined with another treatment, thus making it challenging to determine its isolated impact. Despite this, the case provides valuable insights into how nutritional supplements could potentially play a role in heart disease management.
9
We explored the effectiveness of coenzyme Q10 in treating heart failure by analyzing data from 33 randomized controlled trials. These studies collectively aimed to determine whether coenzyme Q10 could improve outcomes for people suffering from heart disease.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
9
We examined the effectiveness of coenzyme Q10 (CoQ10) in treating acute viral myocarditis (AVM) and the potential benefits of combining it with trimetazidine. A systematic review and meta-analysis were conducted that included data from 16 randomized controlled trials (RCTs) with 1,364 patients.
Our exploration found that patients receiving both trimetazidine and CoQ10 experienced significant improvements in therapy effectiveness compared to those treated with CoQ10 alone. Specifically, the patients undergoing combined treatment had better results regarding myocardial enzyme levels and recovery of heart function.
Notably, the combination therapy did not result in a higher incidence of adverse events when compared to CoQ10 treatment alone. Therefore, we can confidently say that this combination is not only effective but also safe for treating AVM, offering a promising treatment option for those affected.
Our exploration found that patients receiving both trimetazidine and CoQ10 experienced significant improvements in therapy effectiveness compared to those treated with CoQ10 alone. Specifically, the patients undergoing combined treatment had better results regarding myocardial enzyme levels and recovery of heart function.
Notably, the combination therapy did not result in a higher incidence of adverse events when compared to CoQ10 treatment alone. Therefore, we can confidently say that this combination is not only effective but also safe for treating AVM, offering a promising treatment option for those affected.
References
- Loi M, Valenti F, Medici G, Mottolese N, Candini G, et al. Beneficial Antioxidant Effects of Coenzyme Q10 in In Vitro and In Vivo Models of CDKL5 Deficiency Disorder. Int J Mol Sci. 2025;26. doi:10.3390/ijms26052204
- Vučemilović H, Kovač R, Stanišić L, Sanader Vučemilović A, Mrčela D, et al. Is High-Dose Ubiquinone Therapy Before Cardiac Surgery Enough to Reduce the Incidence of Cardiac Surgery-Associated Acute Kidney Injury? A Randomized Controlled Trial. Antioxidants (Basel). 2025;14. doi:10.3390/antiox14020243
- Alghibiwi HK, Alhusiani AM, Sarawi WS, Fadda L, Alomar HA, et al. Coenzyme Q10 and its liposomal form prevent copper cardiotoxicity by attenuating oxidative stress, TLR-4/NF-κB signaling and necroptosis in rats. Cell Mol Biol (Noisy-le-grand). 2025;71:118. doi:10.14715/cmb/2025.70.1.13
- Zhang M, Sun MY, He WY, Yu SF, Ma WC. [Experimental study on the treatment of diabetic cardiomyopathy in rats by using ultrasound-targeted microbubble destruction combined with coenzyme Q10 loaded long-circulating nanoliposomes]. Zhonghua Yi Xue Za Zhi. 2024;104:3765. doi:10.3760/cma.j.cn112137-20240605-01273
- Xu J, Xiang L, Yin X, Song H, Chen C, et al. Efficacy and safety of coenzyme Q10 in heart failure: a meta-analysis of randomized controlled trials. BMC Cardiovasc Disord. 2024;24:592. doi:10.1186/s12872-024-04232-z
- Guo Z, Tian Y, Liu N, Chen Y, Chen X, et al. Mitochondrial Stress as a Central Player in the Pathogenesis of Hypoxia-Related Myocardial Dysfunction: New Insights. Int J Med Sci. 2024;21:2502. doi:10.7150/ijms.99359
- Qazi SU, Bin Naeem MA, Umar M, Zahid MJ, Kan Changez MI, et al. Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis. Future Cardiol. 2024;20:221. doi:10.1080/14796678.2024.2352308
- Intan RE, Balti DR, Nugraha RA, Alkaff FF, Salamah S, et al. Angiotensin converting enzyme inhibitor and coenzyme Q10 as adjunctive treatment for patients with ventricular septal rupture following late onset myocardial infarction: a case report. J Pak Med Assoc. 2024;74:S81. doi:10.47391/JPMA.S6-ACSA-16
- Ali S, Sulaiman E, Dhiaa S. HISTOLOGICAL EFFECTS OF CO ENZYME Q10 ON DOXORUBICIN-INDUCED DEFICITS OF CARDIOPULMONARY AXIS IN WHITE ALBINO RATS. Georgian Med News. 2024.
- Alehagen U, Aaseth J, Schomburg L, Larsson A, Opstad T, et al. Selenoprotein P increases upon selenium and coenzyme Q supplementation and is associated with telomere length, quality of life and reduced inflammation and mortality. Free Radic Biol Med. 2024;222:403. doi:10.1016/j.freeradbiomed.2024.06.027
- Zeng M, Chen Z, Zhang Y, Pang Y. Combination of trimetazidine and coenzyme Q10 for the treatment of acute viral myocarditis: a systematic review and meta-analysis. J Infect Dev Ctries. 2024;18:658. doi:10.3855/jidc.18776
- Du H, Zhao Y, Wen J, Dai B, Hu G, et al. LncRNA DCRT Protects Against Dilated Cardiomyopathy by Preventing NDUFS2 Alternative Splicing by Binding to PTBP1. Circulation. 2024;150:1030. doi:10.1161/CIRCULATIONAHA.123.067861
- Graczyk P, Dach A, Dyrka K, Pawlik A. Pathophysiology and Advances in the Therapy of Cardiomyopathy in Patients with Diabetes Mellitus. Int J Mol Sci. 2024;25. doi:10.3390/ijms25095027
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